Know how Vardenafil 40mg can help with erectile dysfunction with scientific evidence.

 Nowadays, men’s intimate health issues have become a common concerns that affect many men globally. According to a study published in the reputed Journal, the condition of male impotence affects 26 percent of men under the age of 40. 


ED is the inability to maintain a firm erection for a satisfactory intimate act. In this condition, the man, even when stimulated for a intimate activity. There are certain reasons that can rise to ED.; they can be physical or psychological reasons. Poor lifestyle choices, eating habits, and medical conditions. Additionally, the age of a person can also increase the likelihood of getting an ED. 


To achieve successful and satisfactory erection underlies a sequence (cascade) of events, and any hindrance in them causes failure in an erection.


Let’s understand some  underlying factors  & how erectile dysfunction happens:

  1. Psychological Factors:

    • Feelings of stress, anxiety, or depression can mess with the signals between the brain and the body.

    • Some medications used to manage these issues can also cause ED.

    • ED can sometimes cause depression, making the problem worse.

  2. Problems associated with Nerve: 

    • When something sensual excites the brain, it sends messages to relax the blood vessels in the penile region, helping it to become erect.

    • If the nerves are damaged (due to injury or certain diseases), it can stop the brain from sending the right signals, leading to ED.

  3. Hormonal Imbalance:

    • Low testosterone can reduce the desire for intimacy, making it harder to get or keep an erection.

  4. Blood Flow Issues:

    • During arousal, blood flow increases to the penile region, causing an erection.

    • Poor blood flow, caused by conditions like high blood pressure or diabetes, can lead to ED.


But thanks to research and healthcare, there are solutions that can manage such issues, and most commonly, what doctors prescribe are medications that can improve blood flow.


Drugs belonging to the drug class of PDE5 inhibitors are now widely prescribed by healthcare professionals.

Salts like sildenafil, avanafil, tadalafil & vardenafil come under this class. 


In this blog, we will discuss vardenafil 40mg and how it can help in managing erectile dysfunction. 


The drug acts by enhancing the smooth muscle relaxant effects of nitric oxide (NO), a chemical that is normally released in response to sensual stimulation. The smooth muscle relaxation allows increased blood flow into the penile region.  


The NO binds to a component guanylate cyclase, leading to an increase in cGMP levels, which is crucial for achieving an erection. 

Vardenafil is a selective inhibitor of PDE5, which is responsible for the degradation of cGMP. By blocking this enzyme, sildenafil prevents the breakdown of cGMP, allowing it to accumulate more and prolong its effects in relaxing smooth muscles.


Let's explore it with a study : 

The study aimed to test how two doses of vardenafil affected penile rigidity (how firm the erection was) and penile size during erection and to understand how the body absorbs and processes the drug.

What The Study Did: Included 21 men with erectile dysfunction (ED).

  • Study Design: The men took three different treatments on different days: a placebo (fake pill), 20 mg of vardenafil, and 40 mg of vardenafil. The order of treatments was mixed to avoid bias.

  • Measurements: The researchers used a device (Rigiscan) to measure the firmness and fullness of the penile region during sensual stimulation for 2 hours. They also took blood samples to see how the drug was absorbed by the body.

What They Found:

  • Penile Rigidity and Size: After taking the 20 mg and 40 mg doses of vardenafil, the men had stronger and longer-lasting erections compared to the placebo (fake pill). The erections lasted about 42-49 minutes longer than with the placebo. Both doses also showed better results in terms of penile rigidity and size.

  • Side Effects: While the drug was generally well tolerated, the 40 mg dose caused slightly more side effects, including headaches, flushing (feeling of warmth), and nasal congestion compared to the placebo.

The above study found that vardenafil significantly improved erections in men with erectile dysfunction compared to a placebo. It also provided good evidence that vardenafil works well and is generally safe, making it a strong candidate for further testing as a treatment for erectile dysfunction.

So, it is recommended that vardenafil 40mg be taken only if prescribed by a healthcare professional and as guided. There are generic, safe options like Vitara V 40, which contains vardenafil 40mg. However, it is recommended to buy Vitara V 40mg online from reliable sources. 

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